Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cypermethrin | inhibits G6PD in vitro | Oncorhynchus mykiss | |
deltamethrin | inhibits G6PD both in vivo and in vitro, significantly inhibits activity after the 48th hour. Among pesticides, it is the most effective one, which is widely used both at homes and in agricultural fields. Deltamethrin inhibits the enzyme at very low doses, particularly in in vivo conditions, indicating that fish in natural and cultural environments are susceptible to this pesticide and that deltamethrin contaminations can be cause high mortality in fish population, which may lead to the increase in food insufficiency for increasing populations and cause disruption of ecological balance. Thus, usage of deltamethrin must be well controlled | Oncorhynchus mykiss | |
propoxur | inhibits G6PD in vitro | Oncorhynchus mykiss |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oncorhynchus mykiss | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by ammonium sulfate precipitation and affinity chromatography, 1691fold, with a yield of 63% | Oncorhynchus mykiss |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Oncorhynchus mykiss | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
16.24 | - |
purified enzyme | Oncorhynchus mykiss |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + NADP+ | - |
Oncorhynchus mykiss | D-glucono-1,5-lactone 6-phosphate + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G6PD | - |
Oncorhynchus mykiss |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Oncorhynchus mykiss |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1.84 | - |
deltamethrin | - |
Oncorhynchus mykiss | |
2.63 | - |
cypermethrin | - |
Oncorhynchus mykiss | |
16.55 | - |
propoxur | - |
Oncorhynchus mykiss |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.63 | - |
- |
Oncorhynchus mykiss | cypermethrin | |
1.02 | - |
- |
Oncorhynchus mykiss | propoxur | |
12 | - |
- |
Oncorhynchus mykiss | deltamethrin |